Elevated Prolactin Levels Observed Were Similar Between INVEGA HAFYERA™ and INVEGA TRINZA® (paliperidone palmitate)

Percentage of Patients With Increased Prolactin Levels Relative to Maintenance Baseline1

Bar chart depicting percentage of patients with increased prolactin levels

Like other drugs that antagonize dopamine D2 receptors, paliperidone elevates prolactin levels, and the elevation persists during chronic administration. Paliperidone has a prolactin-elevating effect similar to that seen with risperidone, a drug that is associated with higher levels of prolactin than other antipsychotic drugs.

Potentially Prolactin-related Adverse Reactions Observed Were Generally Similar Between INVEGA HAFYERA™ and INVEGA TRINZA®

Percentage of Patients With Potentially Prolactin-related Adverse Reactions2

Chart depicting the percentage of patients with potentially prolactin-related adverse events

REFERENCES: 1. INVEGA HAFYERA™ [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.; August 2021.