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Administration | INVEGA HAFYERA™ (paliperidone palmitate) HCP


This product requires a different preparation and administration than INVEGA SUSTENNA® (paliperidone palmitate) and INVEGA TRINZA® (paliperidone palmitate). It is critical to prepare the medication following the instructions for use to ensure a complete injection of the full dose. Administering less than the full dose could negatively impact the patient’s outcome.


  • INVEGA HAFYERA™ requires longer and faster shaking than INVEGA SUSTENNA®
  • INVEGA HAFYERA™ should be administered by a healthcare professional as a single injection. DO NOT divide dose into multiple injections
  • INVEGA HAFYERA™ is intended for gluteal intramuscular use only. Inject slowly, deep into the muscle taking care to avoid injection into a blood vessel

Instructions for Preparing an INVEGA HAFYERA™ Injection1

Administration step 1: shake syringe with a loose wrist, using a very fast up-and-down motion
Administration step 2: rest briefly and shake the same way with a loose wrist, using a very fast up-and-down motion
Step 3 of administration: proceed immediately to inject INVEGA HAFYERA™

REFERENCE: 1. INVEGA HAFYERA™ [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.; August 2021.