This product requires a different preparation and administration than INVEGA SUSTENNA® (paliperidone palmitate) and INVEGA TRINZA® (paliperidone palmitate). It is critical to prepare the medication following the instructions for use to ensure a complete injection of the full dose. Administering less than the full dose could negatively impact the patient’s outcome.


  • INVEGA HAFYERA™ requires longer and faster shaking than INVEGA SUSTENNA®
  • INVEGA HAFYERA™ should be administered by a healthcare professional as a single injection. DO NOT divide dose into multiple injections
  • INVEGA HAFYERA™ is intended for gluteal intramuscular use only. Inject slowly, deep into the muscle taking care to avoid injection into a blood vessel

Instructions for Preparing an INVEGA HAFYERA™ Injection1

Gloved hand holding syringe with tip pointing up
Gloved hand shaking syringe in an up-and-down motion with tip pointing up
Fully clothed female with back turned to camera

REFERENCE: 1. INVEGA HAFYERA™ [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.; August 2021.